NF is caused by one or more bacteria that attacks the skin, the tissue just beneath the skin subcutaneous tissueand the fascia causing these tissues to die necrosis. Progression of disease is invariable in this group, and a delay in diagnosis can lead to greater soft tissue loss and mortality.
Scarring and disfigurement can also be substantial. Shimizu, Taro, and YasuharuTokuda. InDr Jean-Alfred Fournier described the necrotizing infection of the perineum and scrotumnow called Fournier gangrene. Tissue cultures rather than wound swabs are taken to determine appropriate antibiotic coverage, and antibiotics may be changed in light of results.
It is known to affect the sinuses and soft palate, and can spread very quickly to the brain, often with fatal results.
The researchers found that the bacteria's survival is aided, in large part, by special proteins called transporters, which help feed the microbes in muscle tissue. Government funding, and some supported by private industry, are posted on this government web site.